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Mix-and-match approach boosts immune response of AstraZeneca shot, study finds

Mix-and-match approach boosts immune response of AstraZeneca shot, study finds

14 Sept 00:52 Key points summarised by AI
  • An Oxford study revealed that a mixed-vaccine schedule, specifically administering a Pfizer shot four weeks after an AstraZeneca shot, significantly enhances immune responses compared to two doses of AstraZeneca.
  • All tested mixed combinations of Pfizer and AstraZeneca vaccines generated high concentrations of antibodies against the coronavirus spike protein.
  • The sequence of AstraZeneca followed by Pfizer produced the best T-cell responses and a higher antibody response than Pfizer followed by AstraZeneca.
  • These findings provide support for some European countries that have started offering alternatives to AstraZeneca as a second shot and could offer flexibility for future vaccine rollouts, though the study's size doesn't yet warrant a broad shift from approved schedules.
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